SEQALL Insights Q3 Issue
Welcome to the Q3 edition of SEQALL Insights! 👋 —your bi-monthly update on the latest in multi-omics. This issue is packed with fresh launches, user stories, and practical updates you won’t want to miss:
- Product Launches: 🆕 Introducing DNBSEQ-T7+, MGI’s most powerful high-throughput sequencer to date. With four independent flow cells, redesigned optics, and an integrated workflow, the T7+ delivers up to 35,000 human genomes per year at 30× coverage, setting a new benchmark for speed, scalability, and data quality in large-scale genomics.
- Technology Highlights: 🔬 We dive deep into Stereo-seq OMNI and cutting-edge microbiology advancements; don't forget to read up on the latest spatial breakthroughs published in high-impact journals like Cell and Science.
- User Stories: 🍇 From national headlines to vineyard breakthroughs—see how genomics is transforming New Zealand’s wine and hops industry, and catch our latest podcast discussions.
- Tech Tips: 💡Missed out on our STOmics Microscope Go Optical or spatial webinars livestreamed outside our region? FAQs and full replays are now available on demand..
Let's get started! 👇
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Product LaunchesIntroducing Cycloneseq and PrepAll—short or long? Why not have it all! -
Technology HighlightsCutting-edge spatial breakthroughs in Cell and Science. -
User StoriesFrom national headlines to our own exclusive podcast, catch up on our latest stories and insights. -
Tech TipsCatch up on recent STOmics webinars and FAQs on STOmics microscope Go Optical.
Product Launch
Product Launches: Pushing the Boundaries of Genomics
This quarter, we unveil two major additions to the SEQ ALL portfolio. The DNBSEQ-T7+ “Mammoth” 🐘 and CycloneSEQ-G400ER. These innovations expand MGI’s ecosystem from short- to long-read, setting a new benchmark for flexibility and performance in genomics.
DNBSEQ-T7+ “Mammoth”: Power, Scale & Speed
Our most powerful high-throughput sequencer yet—“Mammoth” delivers up to 35,000 human genomes per year at 30× coverage. With 4 independent flow cells, next-generation optics, and a fully integrated workflow, Mammoth combines scale, speed, and precision in a compact footprint.
Discover 'Mammoth' - Throughput & Speed – Generate more than 14 Tb in 24 hours, doubling the output of the original T7.
- Data Quality – >90% Q40 reads with advanced optics and a next-gen TDI camera system for faster scanning.
- 7-in-1 Integrated Workflow – Automated DNB generation, loading, sequencing, washing, FASTQ file output, onboard bioinformatics and data compression.
- Compact, Scalable Design – higher output and greater efficiency with 1/3 smaller footprint.
- Versatile Applications – population-scale genomics, cancer research, single-cell, spatial, and multi-omics.
CycloneSEQ G400-ER — High-Throughput Nanopore Sequencer
MGI has secured global rights to bring CycloneSEQ technology to market—expanding our SEQ ALL ecosystem with nanopore-based long-read options. The new CycloneSEQ G400-ER offers enhanced accuracy and throughput via improved protein engineering, novel flow cell design, and advanced base-calling algorithms.
G400-ER Product Page - Features a high-density flow cell with 30,000+ nanopores, delivering up to 400 Gb per run in real-time performance
- Supports long reads, base modification detection (e.g. 5mC methylation), and a range of applications: whole-genome resequencing, de novo assembly, full-length transcriptome, and epigenomics
- Offers fast sequencing speeds (100 Mb/min, 350–420 nt/s), high accuracy (≥97% single-read, ≥99.99% overall at 40×), and minimal hardware footprint (3.5 kg) for lab convenience
- Go to Product Page to learn more
Technology Highlights
Recent work featured in leading journals like Cell and Science has leveraged Stereo-seq technology to provide invaluable insights into complex biological phenomena, from the dynamics of embryonic development to the mechanisms of tissue regeneration. These publications collectively showcase the power of Stereo-seq in advancing our understanding of biological processes with spatial context including a Cell cover story that showcases Stereo-seq and DNBelab C Series single-cell sequencing have mapped the macaque claustrum in unprecedented detail, creating a complete spatial transcriptome atlas and whole-brain connectivity map.
Read the papers →
Latest STOmics High Impact Publications
- Transcriptomic analysis revealed 48 cell types, with many enriched in distinct zones
- Claustral glutamatergic cell types are similar to those of insular deep-layer neurons
- Local claustral zones connect to functionally related cortical and subcortical areas
- Retrograde labeling showed nearly all subcortical areas project to macaque claustrum
- Reconstruct full digital embryos at single-cell resolution during early organogenesis
- Generate spatiotemporal atlases and signaling maps for mesoderm and endoderm lineages
- Identify primordium determination zone (PDZ) at the embryonic-extraembryonic interface
- Characterize cross-germ-layer signals contributing to organ primordium formation
- 3D single-cell spatiotemporal multi-omics profiling from Drosophila embryo to pupa
- Multimodal construction of tissue cell-type differentiation trajectories
- Spatiotemporal characterization of tissue development and regulatory networks
- Functional validation of cell-type-specific regulators in the developing midgut
- This study reveals how the loss of regeneration evolved in mammals
- A single gene, Aldh1a2, is crucial for regenerating a lost organ.
- Retinoic acid deficiency directly causes a failure of regeneration in mammals.
- Activating a single gene enhancer can promote regeneration in transgenic mice.
User Stories
From Land to Glass: How Genomics is Shaping New Zealand's Finest Grapes and Hops
We explore how a leading New Zealand research institute is using MGI technology to tackle grapevine pests and diseases, saving growers money and reducing reliance on chemicals. This pioneering work is not only safeguarding the country’s wine industry but also boosting the quality of hops used in craft beer. Watch the video
MGI Podcast
Something About NGS: Conversations at the Cutting-Edge
Join us for in-depth discussions with leading experts, researchers, and visionaries who are at the forefront of genomic exploration. Watch it on MGI Website, MGI YouTube Channel, or listen any time on Spotify.
Tech Tips
STOmics Microscope Go Optical
Go Optical is your high-performance imaging companion in Stereo-seq workflows:
- High resolution: 12-megapixel imaging for clear tissue and single-cell segmentation
- Fast imaging: scan a 10 mm x 10 mm chip in ≤70 seconds using auto-focus and a 10x objective lens
- Large travel range: motorized XY travel range of up to 100 mm x 70 mm, ensuring flexibility for diverse tissue types.
- Accurate results: Minimal stitching errors for reliable spatial data
Frequently Asked Questions
- Q: What are the main applications of Go Optical in spatiotemporal omics?A: Go Optical supports a range of applications, including:
- Fluorescence imaging – for fluorescence-labeled silicon chip samples.
- Brightfield imaging – for pathology-stained silicon chip samples.
- Transmission brightfield imaging – for pathology-stained glass slide samples.
- Q: What certifications does Go Optical have, and where can it be sold?A: Go Optical is certified with RUO-CE and RUO-NRTL, enabling sales in China, North America, the European Union, and Asia-Pacific.
- Q: What are the main components of the STOmics Microscope Go Optical?A: Go Optical consists of both hardware and software:
- Hardware: Microscope, electronic control box, computer host, and display monitor.
- Software: Scanner and TIFF Browser.
Stereo-seq Learning Webinar Series
Catch up on tools and training you may have missed. The Stereo-seq Learning Webinar Series—now available on demand—covers everything from experimental design and fresh frozen performance to spatiotemporal modeling, cell type annotation, and hands-on workflows. Four sessions packed with real-world insights are ready to watch anytime, anywhere.
Stereo-seq Webinar | Stereo-seq V1.3 Landscape and Practical Demo Case
Stereo-seq webinar | Run Stereo seq Experiment from Wet Lab to Dry Lab
Stereo-seq webinar | Spateo | Spatiotemporal Modeling of the Dynamic Processes in a Virtual Embryo
Stereo-seq Webinar-Cell Type Annotation for Large Scale Spatial Omics Algorithms and Performance on Stereo-seq
About Us
MGI Australia and New Zealand is part of MGI Tech Co., Ltd., a global genomics company headquartered in Shenzhen, China. We bring MGI’s advanced sequencing and multi-omics solutions to researchers and partners across Oceania. At MGI Australia and New Zealand, we’re committed to providing best-in-class technical support. Our Brisbane-based support hub, together with team members across the country, ensures local expertise is always within reach.
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About this newsletter
This bi-monthly newsletter delivers concise updates on the latest multi-omics breakthroughs, without overwhelming your inbox. Each edition features key advancements, user experiences, and technical insights. You are receiving this newsletter because you opted in to receive updates from MGI Australia Pty Ltd. Your personal information will be used only to send you news and product information in accordance with applicable privacy laws. You may unsubscribe at any time via the link below or contact us at MGI_Australia@mgi-tech.com.
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SEQALL Insights is brought to you by MGI Australia & New Zealand, providing the latest updates on sequencing technologies, multi-omics innovations, and expert insights.
MGI Australia & New Zealand
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